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Contraindicated (1)pentobarbital decreases amounts of vandetanib by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Stay clear of coadministration with strong CYP3A4 inducers; these medicine lessen exposure to vandetanib by as much as 40%.pentobarbital will lower the level or outcome of trazodone by affecting hepatic/intes
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